Dr. Sirish Kumar Ippagunta
Present affiliation:
Associate Professor,
Department of Biotechnology,
All India Institute of Medical Sciences (AIIMS),
Ansari Nagar,
New Delhi-110029
Email ID: isirishkumar@gmail.com
Phone(O): +91-11-26594609
Academic Qualifications:
| Degree/Diploma | Institution | Years |
| B.Sc. (Biochemistry, Microbiology & Nutrition) | Nagarjuna University, Nagarjuna Nagar, India | 1997 |
| M.Sc. (Biochemistry) | Dr. Ram Manohar Lohia Avadh University, Faizabad, India | 1999 |
| Ph.D. (Molecular epidemiology of Hepatitis E virus) | University of Allahabad, India | 2008 |
Details of Past Appointments :
| Period | Designation | Institution | Nature of Duties |
| April 12, 2015 to April 4, 2018 | Staff Scientist | Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, USA | Research: Innate immunity, Inflammation and Drug development. |
| October 6, 2010 to April 11, 2015 | Postdoctoral research associate | ||
| October 6, 2008 to October 5, 2010 | Postdoctoral research associate | Department of Immunology, St. Jude Children’s Research Hospital, Memphis, USA | Research: Innate immunity and Inflammation. |
| June 2006 to September 2008 | Senior Research Fellow | Departent of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India | Research: Molecular epidemiology of hepatitis E and B viruses. |
| February 2003- May 2006 | Junior Research Fellow | ||
| February 2001- March 2002 | Project assistant | Immunobiology division, Indian Institute of Toxicology Research, Lucknow, India | Research: Immunopharmacology. |
Research Interests:
Innate immunity, Inflammation and Drug development.
Publications:
1) Kuriakose J*, Redecke V*, Guy C, Zhou J, Wu R, Ippagunta SK, Tillman H, Walker PD, Vogel P, Häcker H. Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis. Journal of Clinical Investigation. 2019; 130:2251-2265. * Contributed equally.
2) Ippagunta SK, Pollock JA, Sharma N, Lin W, Chen T, Tawaratsumida K, High AA, Min J, Chen Y, Guy RK, Redecke V, Katzenellenbogen JA, Haecker H. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Science Signaling. 2018 Aug 14;11(543). pii: eaaq1077.
3) Pollock JA*, Sharma N*, Ippagunta SK, Redecke V, Häcker H, Katzenellenbogen J. Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure-Activity Relationships Governing Pan- and Selective Signaling Inhibitors. ChemMedChem. 2018 Aug 16. doi: 10.1002/cmdc.201800417. [Epub ahead of print]. * Contributed equally.
4) Ippagunta SK, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, Redecke V, Häcker H. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function.Proceedings of the National Academy of Sciences of the United States of America 2016; 113: E6162-E6171.
5) Naik A, Gupta N, Goel D, Ippagunta SK, Sharma RK, Aggarwal R. Lack of evidence of hepatitis E virus infection among renal transplant recipients in a disease-endemic area. Journal of Viral Hepatitis 2013; 20: e138-40.
6) Ippagunta SK, Malireddi RK, Shaw PJ, Neale G, Vande Walle L, Fukui Y, Green DR, Lamkanfi M, Kanneganti TD. Addendum: Defective DOCK2 expression in a subset of ASC-deficient mouse lines.
Nature Immunology 2012;13: 701-2.
7) Ippagunta SK, Malireddi RK, Shaw PJ, Neale G, Vande Walle L, Fukui Y, Green DR, Lamkanfi M, Kanneganti TD. The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2- mediated Rac activation and actin polymerization. Nature Immunology 2011; 12: 1010-16.
8) Ippagunta SK, Naik S, Jameel S, Sudha Ramana KN, Aggarwal R. Viral RNA but no replication can be detected in the peripheral blood mononuclear cells of hepatitis E virus infected patients. Journal of Viral Hepatitis. 2011; 18: 668-72.
9) Ippagunta SK, Brand DD, Luo J, Boyd KL, Calabrese C, Stienstra R, Van de Veerdonk FL, Netea MG, Joosten LA, Lamkanfi M, Kanneganti TD. Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis. Journal of Biological Chemistry 2010; 285:12454-62.
10) Malireddi RK, Ippagunta S, Lamkanfi M, Kanneganti TD. Cutting edge: proteolytic inactivation of poly (ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes. Journal of Immunology 2010; 185:3127-30.
11) Ippagunta SK, Naik S, Sharma B, Aggarwal R. Presence of hepatitis E virus in sewage in northern India: frequency and seasonal pattern. Journal of Medical Virology 2007; 79: 1827-31.
12) Sharma S, Kumar SI, Poddar U, Yachha SK, Aggarwal R. Factor V Leiden and Prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in India. Indian Journal of Gastroenterology]
2006; 25: 236-39.
13) Mahtab MA, Kumar SI, Rahman S, Kamal M, Khan M, Aggarwal R. Hepatitis B virus genotypes among chronically infected patients in a tertiary-care hospital in Bangladesh. Indian Journal of Gastroenterology 2006; 25: 219-21.
14) Kumar SI, Kumar A, Srivastava S, Saraswat VA, Aggarwal R. Low frequency of factor V Leiden and Prothrombin gene mutations in patients with hepatic venous outflow tract obstruction in northern India: a case-control study. Indian Journal of Gastroenterology 2005; 24: 211-15.
15) Kumar A, Kumar SI, Pandey R, Naik S, Aggarwal R. Hepatitis B virus genotype A is more often associated with severe liver disease in northern India than is genotype D. Indian Journal of Gastroenterology 2005; 24: 19-22.
16) Kumar P, Paul B, Kumar S, Ali M, Saxena AK. Correlation of cytokine and mobility in mice with arthritis and during therapy with Swertia Chirayita. Journal of Herbal Pharmacotherapy 2004; 4: 33-45.
17) Kumar IV, Paul BN, Asthana R, Saxena A, Mehrotra S, Rajan G. Swertia Chirayita mediated modulation of Interleukin-1β, Interleukin-6, Interleukin-10, Interferon-γ and tumor necrosis factor-α in arthritic mice. Immunopharmacology and Immunotoxicology 2003; 25: 573- 583.
18) Paul BN, Prakash A, Kumar S, Yadav AK, Mani U, Saxena AK, Sahu AP, Lal K, Dutta KK. Silica induced early fibrogenic reaction in lung of mice ameliorated by Nyctanthes arbortristis extract. Biomedical and Environmental Sciences 2002; 15:215-22.
Awards:
• Junior research fellowship from Indian Council of Medical Research (2003-2005).
• Certificate of Merit for the third best paper published in the Indian Journal of Gastroenterology (2006).
• Senior research fellowship from Indian Council of Medical Research (2006-2008).